This paper is really at the edge of my ability to interpret immunology data, but I am a fascinated and eager student all the same. The authors looked at the immunologic landscape of tumor samples across age and sex, reporting not just on the presence of somatic driver mutations but how visible those mutations are to the immune system.Continue reading “Younger Women Less Likely to Respond to Immunotherapy”
Month: August 2020
SNO Brain Mets Conference
Last week the Society for Neuro-oncology (SNO) hosted their second annual brain mets day, and this virtual event was so good that I might have come around on having a brain biopsy. Because it seems like it would be interesting.Continue reading “SNO Brain Mets Conference”
IMpassion131: What happened?
On Thursday, Roche announced that IMpassion131, their phase III evaluating the combination of atezo plus paclitaxel, failed to hits its primary PFS endpoint in previously untreated patients with PD-L1+ metastatic triple-negative breast cancer (TNBC). But wait, you ask. Didn’t they already get approved in that indication? Isn’t it the standard of care? And on Wednesday, the answer was yes; today, it’s more like, Kind of. Because the approval specified nab-paclitaxel (Abraxane). IMpassion131 tested solvent-bound paclitaxel, better known as Taxol. This result is a reminder that these drugs aren’t necessarily interchangeable.
Atezo + Abraxane was granted an accelerated approval in PD-L1+ TNBC, and I would say up front that I don’t think this result creates any risk with the FDA, though label expansion may turn out to be an issue. But there’s a lot about this update that’s intriguing, particularly as it relates to Abraxane and the implications for the next and newest study in the TNBC series, IMpassion132. For patients with TNBC, the news changes the narrative from atezo as a break-from-the-pack wonder drug to its role in a combo and the importance of the chemo backbone.Continue reading “IMpassion131: What happened?”
Update: I want to scream
It would be nice to scream.
The verdict on my voice? Based a perfunctory scope, there’s nothing they can do for me. My vocal cords remain partially paralyzed and won’t open sufficiently, but it can’t be fixed, and why try? I have metastatic cancer. I should worry about that. The shortness of breath? If it gets worse, and I can’t breathe, I should go to the emergency room.
Well, no shit.
I complained about the coughing, the shortness of breath, the fact that my heart rate suddenly jumped from 70 at a brisk walk to a resting 90. He told me other patients have it worse. I’m not other patients. I’m a 35-year-old embarrassed to see casual friends or meet new people, subtly being dropped from external calls at work, struggling on a flight of stairs and overcome with dread when the phone rings.Continue reading “Update: I want to scream”
I lost my voice eight months ago. Not my blog voice, I mean the literal voice that orders coffee and answers the phone.Continue reading “Quiet”